Efficacy and Safety of Growth Hormone (GH) Therapy in Patients with SHOX Gene Variants
Efficacy and Safety of Growth Hormone (GH) Therapy in Patients with SHOX Gene Variants
Blog Article
Background: Among the potential indications for growth hormone (GH) therapy is the presence of mutations in the SHOX (short stature homeobox-containing) gene, located in the telomeric pseudotautosomal region (PAR1) on the short arm of both sex chromosomes.Despite general recommendations supporting GH therapy in these cases, there is a lack of comprehensive evidence specifically evaluating its efficacy and safety in this subgroup of pediatric patients.Aim: The objective of this scoping review was to evaluate the efficacy and safety of growth hormone Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs therapy in patients with SHOX gene variants, providing a narrative synthesis of the included studies.Materials and Methods: This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews.We summarized information extracted from 22 articles identified by our search strategy.
Currently, only one randomized clinical trial has analyzed the efficacy profile of GH in patients with SHOX mutations.Results: Growth hormone is a valuable therapeutic aid for these patients.However, its prescription in children with SHOX Carcass detection and consumption by facultative scavengers in forest ecosystem highlights the value of their ecosystem services gene mutations should consider the specific characteristics of each patient, similar to the approach taken for patients with idiopathic growth hormone deficiency (GHD).Conclusion: Growth hormone therapy in patients with SHOX gene alterations appears to be both safe and effective.However, longitudinal prospective studies and targeted clinical trials are necessary to confirm these findings.
Despite this, GH remains one of the preferred hormonal therapies for patients with short stature and confirmed SHOX gene mutations.